TY - JOUR T1 -福莫特罗和沙美特罗对离体人支气管的松弛作用和作用时间JF -欧洲呼吸杂志JO - Eur Respir J SP - 914 LP - 920 DO - 10.1183/09031936.94.07050914 VL - 7 IS - 5 AU - Naline, E AU - Zhang, Y AU - Qian, Y AU - Mairon, N AU - Anderson, GP AU - Grandordy, B AU - Advenier，C Y1 - 1994/05/01 UR - //www.qdcxjkg.com/content/7/5/914.abstract N2 -本研究的目的是评价福莫特罗和沙美特罗与其他β -肾上腺素受体激动剂在离体人支气管中的效力和疗效(内在活性)及其作用时间。人支气管是在肺癌患者开胸时获得的。效力(-log浓度的药物诱导50%最大放松(-log EC50))和疗效(最大效果(Emax)，对茶碱3 x 10(-3) mol.l-1的反应%)通过分析在静息状态下支气管环或乙酰胆碱10(-3)mol.l-1最大收缩的累积等长浓度-反应曲线来确定。通过评估药物对离体支气管基础张力的松弛活性来测量-肾上腺素能受体激动剂的起效和作用持续时间。就效价而言，所研究物质的等级顺序为福莫特罗和gt;非诺特罗在Or =沙美特罗>Or =异丙肾上腺素>Or =沙丁胺醇> or = adrenaline > or = terbutaline. Formoterol was 150-200 times more potent than isoprenaline. On preparations contracted with acetylcholine 10(-3) mol.l-1 the intrinsic activity (IA) of salbutamol, terbutaline and salmeterol compared with that of isoprenaline ranged 0.62-0.66. Intrinsic activity was higher with formoterol (0.84) and fenoterol (0.75). The onset of action of formoterol (2.14 +/- 0.55 min, n = 11) was not significantly different from that of salbutamol (1.90 +/- 0.24 min, n = 8) but shorter than that of salmeterol (6.40 +/- 1.40 min, n = 10).(ABSTRACT TRUNCATED AT 250 WORDS) ER -