PT -期刊文章盟EJ Jensen AU - B皮德森盟盟- P - E施密特铁刀木AU - R达尔TI -血清嗜酸性阳离子蛋白和乳铁蛋白与吸烟史和肺功能相关的援助- 10.1183 / 09031936.94.07050927 DP - 1994年5月01 TA -欧洲呼吸杂志》第六PG - 927 - 933 - 7 IP - 5 4099 - //www.qdcxjkg.com/content/7/5/927.short 4100 - //www.qdcxjkg.com/content/7/5/927.full所以欧元和J1994可能01;7 AB -一些吸烟者有一个加速肺功能丧失,可能是由于慢性粒细胞参与支气管炎症。嗜酸性粒细胞阳离子蛋白(ECP)和乳铁蛋白(LF)在嗜酸性粒细胞和嗜中性粒细胞颗粒蛋白,分别。我们想调查的关系血清ECP和低频浓度吸烟史和肺功能改变。这部分的横断面,部分前瞻性研究包括98名nonatopic吸烟者和31一生不吸烟者。As participants in a smoking cessation programme, 50 of the 98 smokers ceased smoking for > or = 1 year. Smoking history, lung function and blood samples were obtained at the start of the study, and smokers and ex-smokers also gave blood samples 3, 6 and 12 months later. s-ECP and s-LF were elevated in smokers compared to people who had never smoked. s-ECP was linearly associated with daily cigarette consumption and forced expiratory volume in one second (FEV1) residuals. In a multiple linear regression analysis, low s-ECP and high s-LF were associated with decreased FEV1 residuals. s-ECP and s-LF together accounted for 10.2% of the variation in FEV1 residuals. After smoking cessation, s-ECP and s-LF decreased within 6 months. s-ECP and s-LF are raised in smokers, and may serve as indicators of granulocyte activation. We speculate that they might contribute to prediction of accelerated lung function loss in smokers, but this question needs further investigation in a prospective study.