TY - JOUR T1 -喘息婴儿间隔物的气溶胶释放:日常生活研究摩根富林明-欧洲呼吸杂志》乔和J SP - 850 LP - 856欧元六世- 16 - 5盟詹森,HM盟——Heijnen EM AU -德容,VM AU - Hop, WC盟——荷兰,WP AU - de Jongste JC盟——TiddensHA Y1 - 2000/11/01 UR - //www.qdcxjkg.com/content/16/5/850.abstract N2 -本研究的目的是评估和比较剂量交付和剂量变化的加压计量剂量吸入器(pMDI) /间隔器在老生常谈的婴儿在日常生活和调查影响因素气溶胶交付。在一项开放随机交叉研究中，25名5-26个月的喘息婴儿在家分别测试了金属间隔物(Nebuchamber)、涂有洗涤剂的(DC)和不涂洗涤剂的(nonDC)塑料间隔物(Babyhaler)，为期7天。布地奈德(200微克/天)经Nebuchamber或氟替卡松(125微克/天)经Babyhaler给药。气溶胶被困在过滤器中，位于间隔器和面罩之间。合作记录在日记卡上。测量了间隔层的静电荷(ESC)。通过录像对给药技术进行评价。滤过器的中位数(范围)剂量递送率表示为名义剂量的百分比(%)，Nebuchamber、非DC-Babyhaler和DC-Babyhaler的中位数(范围)剂量递送率分别为34%(3-59)、23%(1-49)和41%(12-55)。 Considerable dose variability was found, median (range) within-subject dose variability, expressed as coefficient of variation, for the Nebuchamber (49% (15-249)) was significantly higher when compared with both nonDC- (36% (12-325)) and DC-Babyhalers (27% (10-122)), for which dose variabilities were similar. Detergent coating was effective to reduce electrostatic charge, and to increase dose delivery, but had no effect on dose variability. Bad cooperation was an important cause for high dose variability for all spacers (r=0.5-0.6, p<0.02). Many mistakes were made during the administration procedure. ER -