TY - T1的香烟存在剂量依赖的相关性与吸烟有关的炎症反应在健康成年人JF -欧洲呼吸杂志》乔和J SP - 1989 LP - 1994欧元六世- 9 - 10盟Kuschner WG AU -达利山德罗,非盟- Wong H AU -布兰科,PD Y1 - 1996/10/01 UR - //www.qdcxjkg.com/content/9/10/1989.abstract N2 -本研究的目的是确定香烟烟雾暴露剂量反应关系和肺细胞和细胞因子浓度在支气管肺泡灌洗(BAL)。落下帷幕落下帷幕上层清液浓度的细胞和肿瘤坏死因子-α(TNF)、白介素(IL) 1β,IL - 6,引发,单核细胞化学引诱物蛋白(MCP) 1来自14个健康的吸烟者和16名健康不吸烟者被量化。Statistically greater concentrations of neutrophils, macrophages, IL-1 beta, IL-6, IL-8 and MCP-1 were observed among smokers compared with nonsmokers (p < or = 0.0007 in all cases). Cigarette smoking, categorized ordinally as: less than one pack, one pack, or greater than one pack per day, was predictive of BAL macrophages (p < 0.0001), neutrophils (p = 0.015), IL-1 beta (p < 0.001) and IL-8 (p = 0.02). We conclude that concentrations of macrophages, neutrophils, IL-1 beta and IL-8 are elevated in the pulmonary microenvironment of smokers in a cigarette dose-dependent manner. Based on the present findings, we would caution against simple analyses that treat current smokers as a homogeneous group and which do not account for smoking intensity. ER -