%0杂志文章%A Hamacher, J %A Sadallah, S %A Schifferli, JA %A Villard, J %A Nicod, LP %T可溶性补体受体1型(CD35)在炎症性肺部疾病支气管肺泡灌洗中的应用%D 1998 %R 10.1183/ 09031936.98.11010112% J欧洲呼吸杂志%P 112- 119% V 11% N 1% X补体受体1型(CR1) (CD35;C3b/C4b受体)是许多造血细胞的跨膜蛋白。一旦被切割，可溶性补体受体1型(sCR1)作为补体的强大抑制剂发挥相反的作用。本研究探讨了正常人和各种炎性疾病患者支气管肺泡灌洗(BAL)中是否存在sCR1的问题，以及其可能的来源。本研究回顾性分析了124例急性和慢性炎症性肺病变患者的标本和临床资料，采用酶联免疫吸附法分析了BAL上清液中sCR1的含量。获得的sCR1水平与BAL成分之间存在相关性。培养人肺泡巨噬细胞，以确定其分泌sCR1的能力。正常受试者的肺泡巨噬细胞在体外可释放sCR1。此外，正常对照组的BAL中存在sCR1，在急性呼吸窘迫综合征(ARDS)、细菌性和卡氏肺囊虫肺炎等急性炎症性肺部疾病以及间质性肺纤维化和结节病等慢性炎症性疾病中明显升高。在ARDS、细菌性肺炎和卡氏P. carinii肺炎的BAL中，sCR1与绝对中性粒细胞计数有良好的相关性。 In sarcoidosis, a correlation was found with BAL lymphocyte counts. Serum sCR1 was not increased in patients compared to controls. Soluble complement receptor type 1 (sCR1) is found in the bronchoalveolar lavage in health as well as in acute and chronic inflammatory disease. Alveolar macrophages are capable of releasing sCR1 in vitro and may be the main physiological source of sCR1 in the alveoli. The good correlation between sCR1 and the absolute neutrophil or lymphocyte numbers in bronchoalveolar lavage of inflammatory diseases suggests a predominant role of leucocytes for the release of sCR1 in such conditions. The release of this inhibitor of complement may be crucial to control and reduce complement activation and thus prevent lung injury. %U //www.qdcxjkg.com/content/erj/11/1/112.full.pdf