AU - Hamacher, J AU - Sadallah, S AU - Schifferli, JA AU - Villard, J AU - Nicod，LP TI -可溶性补体受体1型(CD35)支气管肺泡灌洗的炎症性肺部疾病DP - 1998年1月01 TA -欧洲呼吸杂志》第六PG - 112 - 119 - 11 IP - 1 4099 - //www.qdcxjkg.com/content/11/1/112.short 4100 - //www.qdcxjkg.com/content/11/1/112.full所以欧元和J1998 1月01;11 AB -补体受体1 (CR1) (CD35;C3b/C4b受体)是许多造血细胞的跨膜蛋白。一旦被切割，可溶性补体受体1型(sCR1)作为补体的强大抑制剂发挥相反的作用。本研究探讨了正常人和各种炎症性疾病患者的支气管肺泡灌洗(BAL)中是否存在sCR1及其可能的起源问题。在这项回顾性研究中，包括124例急性和慢性炎症性肺疾病患者的标本和临床资料，采用酶联免疫吸附法分析BAL上清中sCR1。得到的sCR1水平与BAL的成分之间存在相关性。培养人肺泡巨噬细胞，以确定其分泌sCR1的能力。体外实验显示，正常人肺泡巨噬细胞释放sCR1。 In addition, sCR1 was present in BAL of normal controls and was significantly increased in acute inflammatory lung diseases such as acute respiratory distress syndrome (ARDS), bacterial and Pneumocystis carinii pneumonia, as well as in chronic inflammatory diseases such as interstitial lung fibrosis and sarcoidosis. In BAL of ARDS, bacterial, and P. carinii pneumonia, there was a good correlation between sCR1 and the absolute neutrophil counts. In sarcoidosis, a correlation was found with BAL lymphocyte counts. Serum sCR1 was not increased in patients compared to controls. Soluble complement receptor type 1 (sCR1) is found in the bronchoalveolar lavage in health as well as in acute and chronic inflammatory disease. Alveolar macrophages are capable of releasing sCR1 in vitro and may be the main physiological source of sCR1 in the alveoli. The good correlation between sCR1 and the absolute neutrophil or lymphocyte numbers in bronchoalveolar lavage of inflammatory diseases suggests a predominant role of leucocytes for the release of sCR1 in such conditions. The release of this inhibitor of complement may be crucial to control and reduce complement activation and thus prevent lung injury.