Ty-Jour T1 - 传统药物递送的比较与“Venturi”雾化器JF - 欧洲呼吸期刊Jo - Eur Respir J SP - 2479 LP - 2483 VL - 10是 - 11 Au - Devadason,SG Au - everard,ML Au -Linto,JM Au - Le Souef,PN Y1 - 1997/11/01 UR - //www.qdcxjkg.com/content/10/11/2479.Abstract n2 - 尝试改善传统喷气式雾化器的药物送货使用储存系统在呼气期间减少药物浪费。文丘里雾化器在吸入期间增强药物递送,降低治疗时间和药物浪费。该研究研究了与两个文丘里雾化器(Ventstream和Pari LC)相比,使用储存室(Mizer)的常规喷射雾化器(橡子)对常规喷射雾化剂(橡子)对吸入剂量的影响。过滤器附着在四个雾化器系统中,含有Salbutamol和18名患有这些装置吸入的囊性纤维化(3-16 YRS)。使用紫外分光光度法评估过滤器上收集的药物量。使用激光衍射测量每个雾化器系统的气溶胶的粒度分布。使用橡胶的吸气过滤沉积低于橡胶,橡胶和文丘里雾化器。使用带有Mizer的橡胶的过滤沉积低于Pari LC。 No trend with age, height or weight was noted using any nebulizer. Aerosol particle size using the Ventstream was lower than the other nebulizer systems. Drug output from both Venturi nebulizers was more efficient than from the jet nebulizer, used with and without the storage chamber, during inhalation by children with cystic fibrosis. The inhaled dose did not change with the patient's age or size using both types of nebulizer. ER -