TY -的T1 -氟替卡松加沙美特罗对流感嗜血杆菌感染呼吸道粘膜的影响体外JF -欧洲呼吸杂志》乔和J SP - 86 LP - 90欧元六世- 11 - 1 AU -道林,RB AU -约翰逊,米非盟-科尔,PJ AU -威尔逊,R Y1 - 1998/01/01 UR - //www.qdcxjkg.com/content/11/1/86.abstract N2 -流感嗜血杆菌是一种常见的细菌性病原体引起人类呼吸道感染。我们曾表明beta2-agonist氟替卡松加沙美特罗减少铜绿假单胞菌引起的呼吸道粘膜损伤体外。我们已经调查了氟替卡松加沙美特罗对流感嗜血杆菌感染的影响腺样组织扫描电镜的机关文化。Tissue was preincubated with or without salmeterol (4x10(-7)M), prior to infection with H. influenzae and incubated for 12 or 24 h. Infected organ cultures had increased epithelial damage and decreased numbers of both ciliated and unciliated cells at 12h, which were significantly different (p < or = 0.01) from the controls at 24 h. Salmeterol (4x10(-7)M) significantly (p < or = 0.03) reduced damage and loss of ciliated cells in infected organ cultures at both 12 and 24, and significantly (p < or = 0.03) reduced loss of unciliated cells at 24 h. Salmeterol had no effect on the density of bacteria adhering to each individual mucosal feature or the total number of bacteria adhering to the organ culture. These results suggest that salmeterol protects the respiratory epithelium against Haemophilus influenzae-induced damage. The mechanism of salmeterol cytoprotection and its potential clinical relevance remain to be investigated. ER -