PT -期刊文章AU - Ukena, D AU - Harnest, U AU - Sakalauskas, R AU - Magyar, P AU - Vetter, N AU - Steffen, H AU - Leichtl, S AU - Rathgeb, F AU - Keller, A AU - Steinijans，VW TI -吸入类固醇添加茶碱与哮喘吸入类固醇剂量加倍的比较DP - 1997年12月01日TA -欧洲呼吸杂志PG - 2754—2760 VI - 10 IP - 12 4099 - //www.qdcxjkg.com/content/10/12/2754.short 4100 - //www.qdcxjkg.com/content/10/12/2754.full SO - Eur Respir J1997年12月01日;10ab -茶碱的抗哮喘作用可能是哮喘吸入类固醇的补充。本试验的目的是研究在使用400微克x天(-1)的二丙酸倍氯米松(BDP)仍有症状的哮喘患者中，加入茶碱与吸入类固醇剂量增加一倍的效果如何。该试验是在几个欧洲国家进行的随机、双盲、平行组研究。69例患者接受茶碱+ BDP 400微克x天(-1)治疗6周，64例患者接受BDP 800微克x天(-1)治疗。平均+/-SD血清茶碱浓度为10.1+/-4.2 mg x L(-1)。在整个研究过程中进行肺功能测量，患者每天记录呼气峰流量(PEF)、症状和沙丁胺醇的使用情况。两种治疗均显著提高第6周的1秒用力呼气量和PEF (p<0.01)。两组PEF变异性均降低约30%。 There were significant improvements in asthma symptoms and rescue medication use (p<0.001). There were no significant differences between the treatment groups. The study demonstrated clinical equivalence of theophylline plus beclomethasone dipropionate 400 microg x day(-1) and beclomethasone dipropionate 800 microg x day(-1) in patients whose asthma is not controlled on beclomethasone dipropionate 400 microg x day(-1). The results support the use of theophylline as a steroid-sparing agent. The combination of low-dose inhaled steroid plus theophylline is a suitable treatment for moderate asthma.