@文章{Douma2772，作者= {Douma, WR和de Gooijer, A和Rijcken, B和Schouten, JP和Koeter, GH和Weiss, ST和Postma, DS}，标题={基于人群的研究中支气管收缩器反应和支气管扩张器反应之间缺乏相关性}，卷={10}，数={12}，页={2772—2777}，年份= {1997}，doi ={10.1183/09031936.97.10122772}，出版商={欧洲呼吸学会}，188bet官网地址在阻塞性气道疾病患者中，支气管扩张器和支气管收缩器的反应性一直被认为是生理上的相反。在评估严重气道阻塞病例时，刺激挑战已被支气管扩张剂试验所取代。这项研究的目的是在一般人群中检查支气管收缩器和支气管扩张器反应性之间的关系，以及它们的假定互换性。在Vlagtwedde-Vlaardingen的随访研究中，招募了101名成年人(平均年龄55(11)岁，67名男性和34名女性，31名吸烟者)。所有人都完成了关于呼吸道症状的问卷调查。分别使用组胺和特布他林，用累积剂量-反应曲线评估支气管收缩剂和支气管扩张剂的反应性。因此，有可能将气道的组胺敏感性(组胺的浓度，在一秒钟用力呼气量(FEV1)下降10% (PC10))与最大支气管扩张剂反应(delta FEV1)和对支气管扩张剂的敏感性(吸入特布他林的累积剂量，FEV1增加10% (RD10))联系起来。受试者有支气管收缩反应(PC10 \<或= 16 mg x mL(-1);(n= 38)有更多的呼吸道症状(n=63)(40比21 %)和更低的FEV1基线值(90比96 %预测值)，但有相当的支气管扩张剂反应。 Subjects with a bronchodilator response (delta FEV1 \> or = 9\% of the predicted value; n=13) did not differ from those without (n=88) for all parameters, including symptoms, allergy and pulmonary function. In those with a bronchoconstrictor response, there was a weak but significant correlation between the PC10 and RD10 (rho=-0.32), but not between PC10 and delta FEV1. This study suggests that bronchoconstrictor and bronchodilator responsiveness are not highly correlated, even in subjects with airways obstruction. Symptoms were associated with the presence of a bronchoconstrictor, but not a bronchodilator, response. We conclude that bronchoconstrictor and bronchodilator responsiveness are two different phenotypic markers that are not interchangeable in epidemiological studies.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/10/12/2772}, eprint = {//www.qdcxjkg.com/content/10/12/2772.full.pdf}, journal = {European Respiratory Journal} }