TY -的T1 -五年影响鼻持续气道正压在阻塞性睡眠呼吸暂停综合症JF -欧洲呼吸杂志》乔和J SP - 2578 LP - 2582欧元六世- 10 - 11盟Chaouat盟——Weitzenblum E AU -凯斯勒,R AU -奥斯瓦尔德,米非盟-斯福尔扎,E盟——Liegeon MN盟——Krieger J Y1 - 1997/11/01 UR - //www.qdcxjkg.com/content/10/11/2578.abstract N2 -有很少的研究评估的长期生理影响鼻持续气道正压(CPAP)阻塞性睡眠呼吸暂停综合症。因此我们调查前瞻性肺功能的进化,动脉血液气体和肺血液动力学这综合症患者用CPAP治疗。包括六十五名患者。回家用鼻CPAP治疗的平均持续时间是64 + / 6个月。大多数患者(77%)是烟民在基线评估。We observed a small, but significant, decrease in forced expiratory volume in one second (FEV1) from 80+/-21% at baseline (t0) to 76+/-21% of the predicted value at the follow-up evaluation (t5) (p<0.01). Arterial oxygen tension (P[a,O2]) for the group as a whole remained stable (9.4+/-1.5 kPa (71+/-11 mmHg) versus 9.4+/-1.2 kPa (71+/-9 mmHg)). However, P(a,O2) increased in the subgroup of patients with hypoxaemia at t0 (n=23), from 7.8+/-0.7 kPa (59+/-5 mmHg) to 8.9+/-1.2 kPa (67+/-9 mmHg). Arterial carbon dioxide tension (P[a,CO2]) for the group as a whole increased slightly, but significantly, from 5.2+/-0.7 kPa (39+/-5 mmHg) to 5.4+/-0.5 kPa (41+/-4 mmHg) (p<0.05). Mean pulmonary artery pressure (Ppa) at rest did not change (16+/-5 mmHg versus 17+/-5 mmHg; NS) nor did exercising Ppa. In the 11 patients with pulmonary hypertension at t0, Ppa was 24+/-5 mmHg at t0 versus 20+/-7 mmHg at t5 (NS). We conclude that the significant decrease of forced expiratory volume in one second after 5 yr follow-up was related to a high percentage of smokers and exsmokers in the study population. Daytime arterial oxygen tension and pulmonary artery pressure remained stable in an unselected series of 65 obstructive sleep apnoea syndrome patients treated for 5 yrs with nasal continuous positive airway pressure, unlike arterial carbon dioxide tension, which increased by a small, but significant, amount. ER -