TY - JOUR T1 -鼻持续气道正压在阻塞性睡眠呼吸暂停综合征中的五年效应JF -欧洲呼吸杂志JO - Eur Respir J SP - 2578 LP - 2582 DO - 10.1183/09031936.97.10112578 VL - 10 IS - 11 AU - Chaouat, A AU - Weitzenblum, E AU - Kessler, R AU - Oswald, M AU - Sforza, E AU - Liegeon, MN AU - Krieger，目前很少有研究评估鼻持续气道正压通气(CPAP)对阻塞性睡眠呼吸暂停综合征的长期生理影响。因此，我们前瞻性地研究了CPAP治疗该综合征患者的肺功能、动脉血气和肺血流动力学的演变。纳入65例患者。家庭使用鼻CPAP治疗的平均时间为64+/-6个月。基线评估时，大多数患者(77%)为吸烟者。我们观察到1秒用力呼气量(FEV1)从基线(t0)的80+/-21%下降到随访评估(t5)的76+/-21% (p<0.01)。整个组的动脉氧张力(P[a,O2])保持稳定(9.4+/-1.5 kPa (71+/-11 mmHg) vs 9.4+/-1.2 kPa (71+/-9 mmHg))。然而，低氧血症亚组的P(a,O2)在t0时(n=23)升高，从7.8+/-0.7 kPa (59+/-5 mmHg)增加到8.9+/-1.2 kPa (67+/-9 mmHg)。整个组的动脉二氧化碳张力(P[a,CO2])略有增加，但显著，从5.2+/-0.7 kPa (39+/-5 mmHg)增加到5.4+/-0.5 kPa (41+/-4 mmHg) (p<0.05)。 Mean pulmonary artery pressure (Ppa) at rest did not change (16+/-5 mmHg versus 17+/-5 mmHg; NS) nor did exercising Ppa. In the 11 patients with pulmonary hypertension at t0, Ppa was 24+/-5 mmHg at t0 versus 20+/-7 mmHg at t5 (NS). We conclude that the significant decrease of forced expiratory volume in one second after 5 yr follow-up was related to a high percentage of smokers and exsmokers in the study population. Daytime arterial oxygen tension and pulmonary artery pressure remained stable in an unselected series of 65 obstructive sleep apnoea syndrome patients treated for 5 yrs with nasal continuous positive airway pressure, unlike arterial carbon dioxide tension, which increased by a small, but significant, amount. ER -