TY -的T1 -细胞和介质从婴儿急性咽分泌物气喘发作JF -欧洲呼吸杂志》乔和J SP - 2591 LP - 2595欧元六世- 10 - 11盟Counil FP AU -弗兰,B非盟- Segondy M AU -彼得森,C AU -维尔森,米非盟- Bousquet J盟——Arnoux B Y1 - 1997/11/01 UR - //www.qdcxjkg.com/content/10/11/2591.abstract N2 -急性哮喘发作是最常见的严重的下呼吸道感染的婴儿期。呼吸道合胞病毒(RSV)是主要的病原体。为了研究婴儿急性喘息发作期间的炎症，我们想评估咽分泌物诱导的可行性和作用。因此，我们比较了27例伴有呼吸道合胞病毒感染(RSV+)的急性哮喘病发作婴儿和18例未伴有呼吸道合胞病毒感染(RSV-)的急性哮喘病发作婴儿咽部分泌物中的炎症标志物。咽分泌物经等渗盐水理疗恢复。手术的安全性得到了仔细的检查。咽分泌物用二硫苏糖醇匀浆。计数总细胞和嗜酸性粒细胞，测定嗜酸性粒细胞阳离子蛋白(ECP)和组胺水平。咽分泌物诱导的耐受性始终良好。5例RSV+和7例RSV-患者存在嗜酸性粒细胞。 ECP levels were not significantly different between the groups. Histamine levels after protein adjustment were significantly increased in RSV+ patients (p<0.01) in comparison to RSV- patients. In this study, we have shown, that pharyngeal secretion can be safely recovered from infants suffering from acute wheezing episodes, and that it can be analysed for enumeration of inflammatory cells and measurement of inflammatory mediators. ER -