PT -期刊文章盟Roca-Ferrer J盟——Mullol J AU -洛佩兹,E盟——Xaubet盟——Pujols L非盟-费尔南德斯,JC盟——Picado C TI -局部抗炎药对上皮cell-induced嗜曙红细胞生存和gm - csf分泌DP - 1997年7月01 TA -欧洲呼吸杂志》第六PG - 1489 - 1495 - 10的IP - 7 4099 - //www.qdcxjkg.com/content/10/7/1489.short 4100 - //www.qdcxjkg.com/content/10/7/1489.full所以欧元和J1997 7月01;外用抗炎药物可减少嗜酸性粒细胞浸润。这一作用可能是由于上皮细胞释放的产物负责促进嗜酸性粒细胞生存的影响。我们研究了丙酸氟替卡松、布地奈德、二丙酸倍氯米松和奈多罗米钠对体外培养的鼻上皮细胞分泌的粒细胞/巨噬细胞集落刺激因子(GM-CSF)的释放和对嗜酸性粒细胞存活的影响。人上皮细胞条件培养基(HECM)是由接受鼻整形手术的健康受试者培养的上皮细胞生成的。从外周血分离出的常密度嗜酸性粒细胞，分别用药物和非药物产生的HECM孵育。所有药物均抑制嗜酸性粒细胞存活，且反应呈剂量依赖性。丙酸抑制效力最高(25%抑制浓度(IC25) 1 x10 (9) M),紧随其后的是布地奈德(IC25 3.3 x10 (8) M),二丙酸倍氯米松(IC25 1.5 x10 (6) M),和nedocromil钠IC25 5 x10 (6) M)。同样,Fluticasone是最强的类固醇抑制释放gm - csf (IC25 8.4 x10 (-11) M),紧随其后的是布地奈德(IC25 2 x10 (9) M),二丙酸倍氯米松(IC25 13 x10 (8) M),抑制作用与奈多罗米钠(IC25 >10(-5) M)呈显著正相关(r=0.955;术中,0.05)。 Topical anti-inflammatory drugs may decrease eosinophil survival by abrogating the promoting effect of epithelial cells. These drugs may exert part of their therapeutic effect by modulating GM-CSF release. The following rank of potency was observed: fluticasone propionate > budesonide > beclomethasone dipropionate > nedocromil sodium. The study of the interaction between epithelial cells and eosinophils may be a useful method for investigating and comparing the potency of topical drugs.