TY - T1的局部抗炎药对上皮cell-induced嗜曙红细胞生存和gm - csf分泌JF -欧洲呼吸杂志》乔和J SP - 1489 LP - 1495欧元六世- 10 - 7盟Roca-Ferrer J盟——Mullol J AU -洛佩兹,E盟——Xaubet盟——Pujols L非盟-费尔南德斯,JC盟——PicadoC Y1 - 1997/07/01 UR - //www.qdcxjkg.com/content/10/7/1489.abstract N2 -外用消炎药减少嗜酸性粒细胞浸润。这种作用可能是由于促进嗜酸性粒细胞存活的上皮细胞产物的释放。我们研究了丙酸氟替卡松、布地奈德、二丙酸倍氯米松和nedocromil钠对粒细胞/巨噬细胞集落刺激因子(GM-CSF)释放的影响，以及对培养的鼻上皮细胞分泌物诱导的嗜酸性粒细胞存活的影响。人上皮细胞条件培养基(HECM)是由接受鼻矫正手术的健康受试者培养的上皮细胞产生的。从外周血中分离出密度均匀的嗜酸性粒细胞，分别与含或不含药物产生的HECM孵育。所有试验药物均抑制嗜酸性粒细胞存活，且反应呈剂量依赖性。丙酸氟替卡松的抑制效果最高(25%抑制浓度(IC25) 1x10(-9) M)，其次是布地奈德(IC25 3.3x10(-8) M)、二丙酸倍氯米松(IC25 1.5x10(-6) M)和奈多克龙奈钠(IC25 5x10(-6) M)。其次是布地奈德(IC25 2x10(-9) M)、二丙酸倍氯米松(IC25 >10(-5) M)和奈多克龙钠(IC25 >10(-5) M)。术中,0.05)。 Topical anti-inflammatory drugs may decrease eosinophil survival by abrogating the promoting effect of epithelial cells. These drugs may exert part of their therapeutic effect by modulating GM-CSF release. The following rank of potency was observed: fluticasone propionate > budesonide > beclomethasone dipropionate > nedocromil sodium. The study of the interaction between epithelial cells and eosinophils may be a useful method for investigating and comparing the potency of topical drugs. ER -