@文章{De Flora1535，作者= {De Flora, S and Grassi, C and Carati, L}，标题= {n -乙酰半胱氨酸长期治疗对流感样症状的减弱和细胞介导免疫的改善}，卷={10}，数={7}，页数={1535—1541}，年份= {1997}，doi ={10.1183/09031936.97.10071535}，出版商={欧洲呼吸学会}，摘要= {n -乙酰半胱氨酸(NAC)，还原性谷胱甘肽的类似物和前体，188bet官网地址已在临床使用超过30年的粘液溶解药物。一般来说，它也被提议用于和/或用于治疗和/或预防几种呼吸道疾病和涉及氧化应激的疾病。本研究的目的是评估NAC长期治疗对流感和流感样发作的影响。共262名男女受试者(78 % 65岁，62 %患有非呼吸道慢性退行性疾病)被纳入一项涉及20个意大利中心的随机双盲试验。他们随机接受安慰剂或NAC片(600毫克)，每天两次，持续6个月。患有慢性呼吸道疾病的患者不符合条件，以避免NAC对呼吸道症状的影响可能造成混淆。NAC治疗耐受性良好，可显著降低流感样发作的频率、严重程度和卧床时间。NAC组局部和全身症状均显著减轻。在两组中，A/H1N1新加坡6/86流感病毒的血清转化频率相似，但在NAC治疗下，只有25%的病毒感染受试者出现症状形式，而安慰剂组为79%。 Evaluation of cell-mediated immunity showed a progressive, significant shift from anergy to normoergy following NAC treatment. Administration of N-acetylcysteine during the winter, thus, appears to provide a significant attenuation of influenza and influenza-like episodes, especially in elderly high-risk individuals. N-acetylcysteine did not prevent A/H1N1 virus influenza infection but significantly reduced the incidence of clinically apparent disease.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/10/7/1535}, eprint = {//www.qdcxjkg.com/content/10/7/1535.full.pdf}, journal = {European Respiratory Journal} }