PT -期刊文章盟德植物非盟-格拉希,C盟——Carati L TI -衰减流感样症状和改善细胞免疫治疗与长期防治DP - 1997年7月01 TA -欧洲呼吸杂志》第六PG - 1535 - 1541 - 10的IP - 7 4099 - //www.qdcxjkg.com/content/10/7/1535.short 4100 - //www.qdcxjkg.com/content/10/7/1535.full所以欧元和J1997 7月01;AB - n -乙酰半胱氨酸(NAC)是还原性谷胱甘肽的类似物和前体，作为一种溶粘液药物已在临床使用超过30年。一般来说，它也被提议用于和/或用于治疗和/或预防几种呼吸道疾病和涉及氧化应激的疾病。本研究的目的是评估NAC长期治疗对流感和流感样发作的影响。共262名男女受试者(78% >或= 65岁，62%患有非呼吸道慢性退行性疾病)纳入了一项涉及20个意大利中心的随机双盲试验。他们随机接受安慰剂或NAC片(600毫克)，每天两次，持续6个月。患有慢性呼吸道疾病的患者不符合条件，以避免NAC对呼吸道症状的影响可能造成混淆。NAC治疗耐受性良好，可显著降低流感样发作的频率、严重程度和卧床时间。NAC组局部和全身症状均显著减轻。 Frequency of seroconversion towards A/H1N1 Singapore 6/86 influenza virus was similar in the two groups, but only 25% of virus-infected subjects under NAC treatment developed a symptomatic form, versus 79% in the placebo group. Evaluation of cell-mediated immunity showed a progressive, significant shift from anergy to normoergy following NAC treatment. Administration of N-acetylcysteine during the winter, thus, appears to provide a significant attenuation of influenza and influenza-like episodes, especially in elderly high-risk individuals. N-acetylcysteine did not prevent A/H1N1 virus influenza infection but significantly reduced the incidence of clinically apparent disease.