%0杂志文章%A Prescott, E %A Bjerg, AM %A Andersen, PK %A Lange, P %A Vestbo, J %T吸烟对COPD肺功能影响及住院风险的性别差异:《欧洲呼吸杂志》最近的研究结果表明，女性可能比男性更容易受到吸烟对慢性阻塞性肺疾病(COPD)的有害影响。本文研究了性别和吸烟对COPD发展的相互作用，通过肺功能和住院评估。研究人员对13897名1920年以后出生的受试者进行了7-16年的跟踪调查，其中9083人来自哥本哈根城市心脏研究(CCHS)， 4814人来自Glostrup人口研究(GPS)。数据与COPD导致的入院信息相关联。根据横断面数据，在CCHS中，每包年吸烟的女性吸烟者吸入后一秒钟的用力呼气量(FEV1)估计为7.4 mL，男性吸烟者吸入后为6.3 mL。在GPS中，女性和男性对应的FEV1过量损失分别为10.5和8.4 mL。在随访期间，218名CCHS受试者和23名GPS受试者住院。女性与包年相关的风险高于男性(1 - 20,20 -40和>40包年的相对风险(RRs)分别为7.0(3.5-14.1)，9.8(4.9-19.6)和23.3(10.7-50.9)，男性为3.2(1.1-9.1)，5.7(2.2-14.3)和8.4(3.3-21.6)，但性别x包年的交互项未达到显著性(p=0.08)。GPS的结果相似。 After adjusting for smoking in more detail, females in both cohorts had an increased risk of hospitalization for COPD compared to males with a RR of 1.5 (1.2-2.1) in the CCHS and 3.6 (1.4-9.0) in the GPS. This was not likely to be caused by a generally increased rate of hospital admission for females. Results were similar when including deaths from COPD as endpoint. In two independent population samples, smoking had greater impact on the lung function of females than males, and after adjusting for smoking females subsequently suffered a higher risk of being admitted to hospital for COPD. Results suggest that adverse effects of smoking on lung function may be greater in females than in males. %U //www.qdcxjkg.com/content/erj/10/4/822.full.pdf