ty -jour t1-哮喘中姿势引起的气流限制：与血浆儿茶酚胺的关系和吸入的抗胆碱能剂JF-欧洲呼吸杂志-Bevegard，s au -Mossberg，B Y1-1988/05/01 UR -http：//www.qdcxjkg.com/content/content/1/5/458.abstract N2-在十三次哮喘科目中研究了对通气功能的姿势影响连续三天从上午10.00开始。在仰卧前后，在座位位置测量了肺功能。在仰卧位每0.5小时测量峰值呼气流（PEF）。在仰卧之前，期间和之后，收集了用于测定血浆儿茶酚胺的血液样本。在最初的肺功能测试后，吸入安慰剂或溴化溴（0.125 mg）。在第三天，整个试验都没有任何药物作为对照实验。在安慰剂日，仰卧倾斜会引起PEF的初始，快速下降，然后在四个小时内逐渐减少。PEF的进行性减少显然是由支气管收缩引起的。 Ipratropium bromide prevented this posture-induced bronchoconstriction. On the day seated there was also a tendency towards a decline of PEF though less pronounced than in the supine position on the placebo day. No significant alterations in plasma levels of catecholamines were observed. We conclude that the supine posture is a stimulus to bronchoconstriction in asthma, likely to be involved in nocturnal wheezing. Postural bronchoconstriction is not explained by lowered plasma levels of adrenaline, as has been suggested for nocturnal asthma. The results raise the question of whether cholinergic mechanisms are involved. ER -