TY -的T1 Posture-induced气流限制在哮喘:血浆儿茶酚胺和吸入抗胆碱能代理关系JF -欧洲呼吸杂志》乔和J SP - 458 LP - 463欧元六世- 1 - 5 AU -拉尔森,K盟——Bevegard S盟——Mossberg B Y1 - 1988/05/01 UR - //www.qdcxjkg.com/content/1/5/458.abstract N2 -姿势影响通气功能研究十三哮喘受试者连续三天从10.00开始。在仰卧4小时前后测定坐位肺功能。仰卧位每0.5 h测量一次呼气峰值流量(PEF)。在仰卧前、卧中、卧后采集血浆儿茶酚胺。在初始肺功能测试后，吸入安慰剂或异丙托溴铵(0.125 mg)。在第三天，整个试验都是坐着进行的，没有任何药物，作为对照实验。在服用安慰剂的那一天，仰卧时PEF开始迅速下降，随后在4小时内逐渐下降。PEF进行性下降明显是由支气管收缩引起的。异丙托溴铵可防止这种姿势引起的支气管收缩。在坐着的那一天，PEF也有下降的趋势，尽管没有安慰剂那一天仰卧位的情况明显。 No significant alterations in plasma levels of catecholamines were observed. We conclude that the supine posture is a stimulus to bronchoconstriction in asthma, likely to be involved in nocturnal wheezing. Postural bronchoconstriction is not explained by lowered plasma levels of adrenaline, as has been suggested for nocturnal asthma. The results raise the question of whether cholinergic mechanisms are involved. ER -