TY - T1的诱发因素在慢性阻塞性肺疾病细菌殖民化JF -欧洲呼吸杂志》乔和J SP - 343 LP - 348欧元六世- 13 - 2非盟Zalacain R盟——Sobradillo V盟——Amilibia J AU -巴伦,J盟——Achotegui V盟——Pijoan霁AU -略伦特,JL Y1 - 1999/02/01 UR - //www.qdcxjkg.com/content/13/2/343.abstract N2 -本前瞻性观察性研究的目的是确定这些因素影响细菌殖民化患者稳定的慢性阻塞性肺病(COPD)。八十八年门诊病人稳定COPD患者和20名正常的肺量测定法和胸部x线摄影(控制)fibreoptic支气管镜检查与局部气溶胶麻醉。Bacterial colonization was determined using the protected specimen brush (PSB) with a cut-off > or = 10(3) colony-forming units (CFU x mL(-1)). The influence of age, degree of airflow obstruction, smoking habit, pack-yrs of smoking, and chest radiographic findings on bacterial colonization were assessed by univariate and multivariate analysis. Significant bacterial growth was found in 40% of patients and in none of the controls. Haemophilus influenzae, Streptococcus viridans, S. pneumoniae and Moraxella catarrhalis were the most frequent pathogens. After adjustment for other variables, severe airflow limitation (odds ratio (OR) 5.11, 95% confidence interval (CI) 1.45-17.9) and current smoking (OR 3.17, 95% CI 2.5-8) remained associated with positive bacterial cultures. When only potentially pathogenic micro-organisms were considered, significant bacterial growth was found in 30.7% of patients, with severe airflow obstruction (OR 9.28, 95% CI 2.19-39.3) being the only variable independently associated with positive bacterial cultures. Our results show that stable chronic obstructive pulmonary disease patients have a high prevalence of bacterial colonization of distal airways which is mainly related to the degree of airflow obstruction and cigarette smoking. ER -