TY - JOUR T1 - Inflammatory cells as well as epithelial cells in nasal polyps express vascular endothelial growth factor JF - European Respiratory Journal JO - Eur Respir J SP - 367 LP - 372 DO - 10.1034/j.1399-3003.2000.15b24.x VL - 15 IS - 2 AU - Coste, A AU - Brugel, L AU - Maitre, B AU - Boussat, S AU - Papon, JF AU - Wingerstmann, L AU - Peynegre, R AU - Escudier, E Y1 - 2000/02/01 UR - //www.qdcxjkg.com/content/15/2/367.abstract N2 - In nasal polyps (NPs), locally secreted growth factors are involved in the remodelling of the epithelium and extracellular matrix but little is known concerning vessel remodelling.动脉内延生长因子原位表达法(VEGF)得到了评价,VEGF体外分解法从鼻膜细胞初级人文文化中量化VEGF表达式评价NP(n=14)和CM(n=6)在空气/液界面培养的HNECs超常量中,VEGF通过免疫测定、基准条件和变换生长因子-Beta1(TGF-Beta1)启发实现量化HNEC解析器中,VEGF和VEGF送信器RibonulecliceVEGF实战率比CM高(六分之三)(p<0.05)和NP子院高(14分之六)比CM高(六分二)(nucle)。在基准条件下,VEGF中HNE文化介质集中度从2天增长到4天,然后下降并变得不可检测VEGF经TGF-BetaHNEC解析中,VEGF和VEGF mRNA在文化第四十四天检测得出的结论是脉冲内延生长因子在鼻膜聚变物中以强烈原位表达,主要表现在炎症细胞中,但也表现在上膜细胞中。人类鼻部细胞能分辨体外脉冲内延生长因子变换生长因子比特1提高调控这表明脉冲内延生长因子诱导odema和angio生成可能与鼻膜聚变原型相关ER-