TY - JOUR T1 -非肥胖和肥胖患者阻塞性睡眠呼吸暂停的头测量异常JF -欧洲呼吸杂志JO - Eur Respir J SP - 403 LP - 410 VL - 13 IS - 2 AU - Sakakibara, H AU - Tong, M AU - Matsushita, K AU - Hirata, M AU - Konishi, Y AU - Suetsugu，S Y1 - 1999/02/01 UR - //www.qdcxjkg.com/content/13/2/403.abstract N2 -这项工作的目的是全面评估日本阻塞性睡眠呼吸暂停(OSA)患者的头影测量特征，并阐明头影测量变量与呼吸暂停严重程度之间的关系。在37名健康男性和114名男性OSA患者中测量了48个头侧测量变量，这些患者被分为54名非肥胖(身体质量指数(BMI) <27 kg x m(-2)，呼吸暂停-低通气指数(AHI)=25.3+/-16.1事件x h(-1))和60名肥胖(BMI >or = 27 kg × m(-2)， AHI=45.6+/-28.0 events h(-1))组。诊断性多导睡眠描记术对所有OSA患者和19名正常对照组进行了检查。与bmi匹配的正常对照组相比，非肥胖OSA患者表现出一些头影测量缺陷:1)颅底、上颌骨和下颌骨的面部A-P距离减小，骨咽宽度减小;2)舌体积增大，舌体积移位不足;3)软腭增大;4)舌骨下位;5)上气道宽度在4个不同水平均有降低。 More extensive and severe soft tissue abnormalities with a few defects in craniofacial bony structures were found in the obese OSA group. For the non-obese OSA group, the stepwise regression model on AHI was significant with two bony structure variables as determinants: anterior cranial base length (S-N) and mandibular length (Me-Go). Although the regression model retained only linear distance between anterior vertebra and hyoid bone (H-VL) as an explainable determinant for AHI in the obese OSA group, H-VL was significantly correlated with soft tissue measurements such as overall tongue area (Ton), inferior tongue area (Ton2) and pharyngeal airway length (PNS-V). In conclusion, Japanese obstructive sleep apnoea patients have a series of cephalometric abnormalities similar to those described in Caucasian patients, and that the aetiology of obstructive sleep apnoea in obese patients may be different from that in non-obese patients. In obese patients, upper airway soft tissue enlargement may play a more important role in the development of obstructive sleep apnoea, whereas in non-obese patients, bony structure discrepancies may be the dominant contributing factors for obstructive sleep apnoea. ER -