@article {agusti934，作者= {Agusti，Ag和Carrera，M和Barbe，F和Munoz，A and Togores，B}，title = {慢性阻塞性肺疾病的氧气治疗}，体积= {14}，数量= {14}，数字= {4}，页面= {934--939}，年= {1999}，Publisher = {欧洲呼吸社会}，摘要=188bet官网地址 {venturi masks（vms）和鼻prongs（nps）被广泛用于治疗急性呼吸衰竭（ARF）在慢性阻塞性肺疾病（COPD）中。在这项研究中，这些装置的潜力是使呼吸酸中毒恶化的潜力以及它们保持足够（\> 90 \％）动脉氧合（SA，O2）的能力（约24小时）。在一项随机跨界研究中，研究了18名因ARF而需要住院的COPD患者。在确定基线动脉血气水平（在房间空气上）之后，将患者随机通过VM或NP进行氧疗法，以最低可能的灵感氧分子，导致最初的SA，O2的初始SA，O2的\> OR = 90 \％。在30分钟后（O2上）再次测量动脉血液水平，然后在随后的24小时内使用计算机记录的SA，O2。然后，通过替代装置（NPS或VM）将患者越过以接受O2治疗，并以相同的顺序再次获得相同的测量。观察到，VM和NP都以相同的程度（P = NS）改善了动脉氧张力（P \ <0.0001），对动脉二氧化碳张力或pH没有任何显着影响。然而，尽管使用VM，SA，O2的最初氧合为3.7 +/- 3.8 h，使用NPS（p \ <0.05）为5.4 +/- 5.9 h。 Regression analysis showed that the degree of arterial hypoxaemia (p\<0.05) and arterial hypercapnia (p\<0.05) present before starting O2 therapy and, particularly, the initial Sa,O2 achieved after initiation of O2 therapy (p\<0.0001) enabled the time (in h) that patients would be poorly oxygenated (Sa,O2 \< 90\%) on follow-up to be predicted. These findings suggest that, in order to maintain an adequate (\> 90\%) level of arterial oxygenation in patients with chronic obstructive pulmonary disease and moderate acute respiratory failure: 1) the initial arterial oxygen saturation on oxygen should be maximized whenever possible by increasing the inspiratory oxygen fraction; 2) this strategy seems feasible because neither the VM nor NPs worsen respiratory acidosis significantly; and 3) the Venturi mask (better than nasal prongs) should be recommended.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/14/4/934}, eprint = {//www.qdcxjkg.com/content/14/4/934.full.pdf}, journal = {European Respiratory Journal} }