PT -期刊文章AU -戴维斯,RJ AU -班纳特LS AU - Barbour, C AU - Tarassenko, L AU - Stradling, TI - Second by second patterns in cortical electroencephalograph and systolic blood pressure during Cheyne-Stokes DP - 1999 Oct 01 TA - European Respiratory Journal PG - 940--945 VI - 14 IP - 4 4099 - //www.qdcxjkg.com/content/14/4/940.short 4100 - //www.qdcxjkg.com/content/14/4/940.full SO - Eur Respir J1999 Oct 01; 14 AB - Little is known about how arousal develops during the ventilatory phase of Cheyne-Stokes breathing. This study employs neural network analysis of electroencephalograms (EEGs) to describe these changes and relate them to changes in systolic blood pressure, which is probably a subcortical marker of arousal. Six patients with Cheyne-Stokes respiration (apnoea/hypopnoea index 32-69 h(-1)) caused by stable chronic heart failure underwent polysomnography including arterial beat-to-beat systolic blood pressure determination. Periods of 15 sequential apnoeas during nonrapid eye movement sleep were identified for each subject. For each apnoea, the EEG was examined second-by-second using neural net analysis from 28 s before to 28 s after apnoea termination (first return of oronasal airflow), and this was compared with the systolic blood pressure pattern. During the apnoeic phase, sleep deepened progressively. Arousal started to develop at or just before apnoea termination and progresses through the breathing phase. The rise and fall in the systolic blood pressure closely followed the rise and fall in electroencephalographic sleep depth. In conclusion, during Cheyne-Stokes breathing, cortical electroencephalographic arousal begins at or just before the resumption of breathing. Cortical electroencephalographic sleep depth changes are closely mirrored by changes in arterial systolic blood pressure, suggesting that the state changes in the cortical and basal brain structures may be synchronous.