TY - JOUR T1 - ICAM-1 mediates lung leukocyte recruitment but not pulmonary fibrosis in a murine model of bleomycin-induced lung injury JF - European Respiratory Journal JO - Eur Respir J SP - 71 LP - 77 VL - 13 IS - 1 AU - Matsuse, T AU - Teramoto, S AU - Katayama, H AU - Sudo, E AU - Ekimoto, H AU - Mitsuhashi, H AU - Uejima, Y AU - Fukuchi, Y AU - Ouchi, Y Y1 - 1999/01/01 UR - //www.qdcxjkg.com/content/13/1/71.abstract N2 - Bleomycin-induced lung injury has been extensively used as a model of interstitial pneumonia and pulmonary fibrosis.细胞间粘合分子-ICAM-I这份报告的目的是调查ICAM-1/LFA-1alpha路径在分片诱导肺损伤模型中的作用动物接收75mgxkgmg(-1)blumycin后用磷酸盐缓冲盐类、反ICAM-1和LFA-1alpha单片抗体处理分片混凝液、水分素内容和语理学发现数在这些组间比较BLM组中7和14天观察总细胞计数、宏计数和BAL流体中微量计数BLM+mAb群中Blemycin诱发的内核累积数在第7和第14天大为减少(p<0.01)。mAb对ICAM-1和LFA-1alpha的管理没有减少肺水分分或组织式纤维分数分数,表明ICAM-I和LFA-1pha的对立没有减低Belomycin诱发肺部纤维化细胞间粘合分子-1/淋巴细胞函数关联反原-1alpha路径介质然而,其他机制对随后开发肺纤维化很重要。ER-