Ty-杂志T1-囊性纤维化的肺部恶化的处理导致改善抗氧化剂状态JF-欧洲呼吸杂志JO -EUR RESSIR J SP -560 LP -564 LP -564 VL -13 IS -3 AU -3 AU -RANGE -RANGE，SP AU -DUNSTER，C AU -DUNSTER，C AU，C AU，C AU-KNOX，AJ AU -KELLY，FJ Y1-1999/03/01 UR -http：//www.qdcxjkg.com/content/13/3/3/560.Abstract N2-许多囊性纤维化（CF）患者的循环水平增加了氧化产物和/或抗氧化剂状态降低。这项研究研究了肺部加重的治疗是否会减少CF患者的氧化应激。在接受静脉注射抗生素治疗的开始和结束时，对17例成年患者进行了研究。抗氧化剂抗坏血酸，α-生育酚，尿酸和总硫醇的血浆浓度以及血浆视黄醇，脂质氢过氧化物，丙二醛和蛋白羰基水平的水平。使用Wilcoxon签名的等级测试比较中位（四分位间范围）预处理和治疗后水平。临床分辨率通过改进的肺活量测定法反映。在血浆抗坏血酸（前30.4（15.7-38.6）Microm，35.2（27.3-49.6）microm）中观察到显着增加，α-生育酚（Pre 19.7（13.6-25.2）Microm，Pre to Pre Microm，后25.2（19.3-31.6）Microm）和视黄醇（1.9（1.5-2.5）MIRCOM，后2.7（1.7-3.5）microm）。 No change in plasma total reduced thiols occurred following treatment (pre 409 (366-420) microM, post 392 (366-423) microM), whereas uric acid fell with treatment (pre 307 (274-394) microM, post 260 (216-317) microM). Neither plasma protein carbonyls or malondialdehyde levels altered with treatment (protein carbonyls pre 0.47 (0.28-1.27), post 0.67 (0.42-0.83) nM x mg protein(-1); malondialdehyde pre 0.75 (0.53-1.18), post 0.84 (0.65-1.15) microM). Lipid hydroperoxides levels did decrease following treatment (53 (18-85) versus 17 (10-55) nM). This study demonstrated that treatment of infective exacerbations resulted in increased plasma levels of some antioxidant vitamins. No immediate change in plasma protein oxidation was observed, but lipid oxidation was decreased. ER -