TY - T1的突发性哮喘发作:临床特点,对治疗的反应,随访2周。多中心气道研究协作(MARC)调查摩根富林明-欧洲呼吸杂志》乔和J SP - 266 LP - 273欧元六世- 15 - 2非盟-巴尔,RG AU -半圆,PG AU -克拉克,非盟- Camargo CA, Jr Y1 - 2000/02/01 UR - //www.qdcxjkg.com/content/15/2/266.abstract N2 -突发性哮喘急性加重可能有不同的触发和响应比slower-onset治疗急性加重。作者研究了这一假说患者严重哮喘发作。多中心气道研究协作前瞻性的患者呈现64年北美紧急部门哮喘急性加重。Of 1,847 patients aged 18-54 yrs, 900 had severe exacerbations (peak expiratory flow rate (PEFR) <50% predicted or hospitalized without PEFR). These patients were divided into sudden-onset (< or =3 h of symptoms) and slower-onset (>3 h of symptoms) groups. Fourteen per cent (95% confidence interval, 11-16%) of patients with severe asthma exacerbations had sudden-onset exacerbations. Sudden-onset patients were similar to slower-onset patients, except triggers of their exacerbations were more often respiratory allergens, exercise or psychosocial stress and less often respiratory infections. Sudden-onset patients were more likely to have used oral beta-agonists and salmeterol in the preceding 4 weeks. Although initial PEFRs and management were similar, sudden-onset patients had a greater improvement in PEFR (35 versus 28% p<0.001). Sudden-onset patients were less often discharged on systemic corticosteroids, but had similar 2-week relapse rates compared with slower-onset patients. Among patients presenting with severe asthma exacerbations, sudden-onset exacerbations had a different pattern of triggers and greater improvement with treatment than slower-onset exacerbations. ER -