TY - T1的支气管炎症的急性细菌性急性加重慢性支气管炎:白三烯B4摩根富林明的角色——欧洲呼吸杂志》乔和J SP - 274 LP - 280欧元六世- 15 - 2非盟骗子SW AU -贝利,DL AU -希尔,SL盟——Stockley RA Y1 - 2000/02/01 UR - //www.qdcxjkg.com/content/15/2/274.abstract N2 -中性粒细胞招募气道慢性阻塞性肺疾病(COPD)被认为调解组织的破坏。中性粒细胞招募期间增加细菌发作。炎症过程研究了慢性阻塞性肺病急性加重的患者为了确定白三烯B4 (LTB4)的作用。八个主题的痰中性粒细胞产品细菌COPD恶化的原因进行了分析(髓过氧物酶、弹性蛋白酶)和化学引诱物(interleukin-8(引发)和LTB4)。LTB4的贡献的趋化活性痰溶胶阶段使用LTB4受体拮抗剂LY293111决心。急性期血清蛋白的浓度alpha1-proteinase抑制剂,alpha1-antichymotrypsin和c反应蛋白测定。所有患者都进行适当的广谱抗生素治疗7 - 14天。最初,痰髓过氧物酶活性高,表明嗜中性粒细胞涌入;这是与高水平的引发和LTB4有关。All these concentrations fell with treatment (p<0.01). The chemotactic activity of the sputum was raised on presentation and fell with treatment (p<0.01). LTB4 contributed approximately 30% of the total chemotactic activity on presentation; this diminished with therapy. All acute phase proteins were raised on presentation and fell with therapy (p<0.01). These findings suggest that leukotriene B4 contributes to neutrophil influx into the airway in chronic obstructive pulmonary disease and may influence disease progression. ER -