TY - T1的高程与哮喘有关的总血清免疫球蛋白E nonallergic个人JF -欧洲呼吸杂志》乔和J SP - 609 LP - 614欧元六世- 16 - 4盟Beeh公里盟——Ksoll M盟——镶嵌细工,R Y1 - 2000/10/01 UR - //www.qdcxjkg.com/content/16/4/609.abstract N2 -升高血清免疫球蛋白(Ig) E是特异反应性的标志,并有助于在过敏性哮喘和支气管高反应性的个人。相比之下，IgE在非过敏受试者中的意义就不那么明显了。本研究的目的是阐明在无临床过敏的情况下IgE与哮喘的潜在联系。为此目的，对1219名连续的肺部病人进行了评估。非过敏患者以皮肤点刺试验阴性、特异反应史、特异性IgE为标准，509例(42%)为非过敏。其中80例患者(16%)总IgE水平升高(>150 U x mL(-1))。将IgE>150 U x mL(-1)的非过敏受试者与IgE正常受试者的哮喘患病率和严重程度进行比较，所有非过敏受试者和哮喘患者的肺功能参数与血清IgE相关。哮喘在IgE水平升高的非过敏受试者中比IgE正常的非过敏受试者中更普遍(39%对14%;术中,0.001)。非过敏性哮喘患者的肺功能值因预测的1秒用力呼气量(FEV1)%而降低(66+20% vs 83+/-17%; p<0.001), FEV1% forced vital capacity (FVC) (70+/-14% versus 81+/-8%; p<0.001) and forced mid expiratory flow (FEF25-75) (1.7+/-0.9 L x s(-1) versus 2.8+/-0.9 L x s(-1); p=0.002) in patients with high IgE compared to asthmatics with normal IgE, and were negatively correlated with log IgE levels in all nonallergic asthmatics. (FEVI % pred: r=-0.5, p<0.001; FEV1% FVC: r=-0.53, p<0.001; FEF25-75: r=-0.52, p<0.001). In the whole study population, multivariate analysis showed a greater than fivefold asthma risk for nonallergic individuals with serum IgE>150 U x mL(-1). These data support the role of IgE as risk factor for asthma independent of allergy, and they further challenge the definition of intrinsic asthma as "non-IgE mediated" entity. ER -