TY -的T1 -特异性神经元烯醇酶在诊断接头nosis of small-cell lung cancer with pleural effusion: a negative report JF - European Respiratory Journal JO - Eur Respir J SP - 698 LP - 700 VL - 1 IS - 8 AU - Pettersson, T AU - Klockars, M AU - Froseth, B Y1 - 1988/08/01 UR - //www.qdcxjkg.com/content/1/8/698.abstract N2 - We measured the concentration of neuron-specific enolase (NSE) and carcinoembryonic antigen (CEA) in the serum and pleural fluid of 53 patients with pleural effusions, including seven patients with small-cell lung cancer (SCLC). High levels (above 12.5 micrograms.l-1) of NSE in pleural fluid were observed in five patients with SCLC (sensitivity 71%). However, pleural fluid NSE levels were also increased in five patients with other types of cancer and in four patients with non-malignant inflammatory diseases (specificity 80%). We conclude that although SCLC with pleural effusion can be associated with elevated pleural fluid NSE activity, this increase in enzyme levels is not specific for malignancy. ER -