PT -期刊文章AU -佩特森,T非盟- Klock纽约ars, M AU - Froseth, B TI - Neuron-specific enolase in the diagnosis of small-cell lung cancer with pleural effusion: a negative report DP - 1988 Aug 01 TA - European Respiratory Journal PG - 698--700 VI - 1 IP - 8 4099 - //www.qdcxjkg.com/content/1/8/698.short 4100 - //www.qdcxjkg.com/content/1/8/698.full SO - Eur Respir J1988 Aug 01; 1 AB - We measured the concentration of neuron-specific enolase (NSE) and carcinoembryonic antigen (CEA) in the serum and pleural fluid of 53 patients with pleural effusions, including seven patients with small-cell lung cancer (SCLC). High levels (above 12.5 micrograms.l-1) of NSE in pleural fluid were observed in five patients with SCLC (sensitivity 71%). However, pleural fluid NSE levels were also increased in five patients with other types of cancer and in four patients with non-malignant inflammatory diseases (specificity 80%). We conclude that although SCLC with pleural effusion can be associated with elevated pleural fluid NSE activity, this increase in enzyme levels is not specific for malignancy.