Barcelo % 0期刊文章%,%产生,C % Barbe F %维拉,M %脑桥,S % Agusti AG) % T异常睡眠呼吸暂停患者的脂质过氧化作用% D J欧洲呼吸杂志2000% % P 644 - 647 X % V 16% N 4%心血管疾病的患病率增加阻塞性睡眠呼吸暂停综合征患者(群)。动脉氧合的兴衰,每个呼吸暂停可能增加脂质过氧化作用,有助于解释这种关联。在目前的研究中,作者决定群患者的脂质过氧化反应和治疗的效果持续气道正压(CPAP)。十四岁男性患者严重的群(59 + / 5呼吸暂停x h(1))(+钙)和13健康不吸烟、年龄相仿的男性志愿者进行了研究。CPAP治疗后患者在诊断和学习1年以上(> 4 h x晚上(1))。静脉血样本获得整夜禁食后清晨。患者群,样本之前和期间的睡眠也获得。低密度脂蛋白(LDL)粒子被顺序超速离心法分离。氧化的程度是由硫代巴比土酸测定(TBARs),及其容易氧化的测量滞后阶段。患者群显示更高TBARs(28.1 + / - -2.8和20.0 + / - -1.8 nmol x丙二醛mgLDL蛋白质(1),p = 0.02)和较短的迟滞期值(83.8 + / - -3.4和99.7 + / - -3.4分钟,p = 0.005)比控制。 These differences were not due to the smoking status of the patient. Likewise, these values did not change significantly throughout the night yet, the lag phase value was significantly improved by treatment with CPAP (124.9+/-8.5 min; p<0.001). These results indicate that obstructive sleep apnoea syndrome is associated with abnormal lipid peroxidation and that this is improved by chronic use of Continuous positive airway pressure. These results can contribute towards explaining the high prevalence of cardiovascular diseases seen in Obstructive sleep apnoea syndrome. %U //www.qdcxjkg.com/content/erj/16/4/644.full.pdf