RT期刊文章SR电子T1异常脂质过氧化作用在患者睡眠呼吸暂停摩根富林明欧洲呼吸杂志乔和J FD欧洲呼吸学会SP 644欧元OP 647签证官16是4 A1 Barcelo, A1产生,C A1 Barbe F A1维拉,M A1脑桥,年代A1 Agusti, AG)年2000 UL htt188bet官网地址p://www.qdcxjkg.com/content/16/4/644.abstract AB心血管疾病的患病率增加阻塞性睡眠呼吸暂停综合征患者(群)。每次呼吸暂停后动脉氧合的下降和上升可能增加脂质过氧化，有助于解释这种联系。在目前的研究中，作者测定了osa患者的脂质过氧化和持续气道正压(CPAP)治疗的效果。研究了14例重度OSAS(59+/-5呼吸暂停x h(-1)) (+/-SEM)男性患者和13名年龄相近的健康不吸烟男性志愿者。患者在确诊和CPAP治疗后进行了1年以上的研究(>4小时x夜(-1))。空腹一晚后，在清晨采集静脉血样本。在osa患者中，也获得了睡眠前和睡眠期间的样本。通过连续超离心分离低密度脂蛋白(LDL)颗粒。它们的氧化水平由硫代巴比妥酸测定法(TBARs)测定，其氧化敏感性由滞后相测定法测定。与对照组相比，OSAS患者tbar更高(28.1+/-2.8 vs 20.0+/-1.8 nmol x丙二醛x mgLDL蛋白(-1)，p=0.02)，滞后期值更短(83.8+/-3.4 vs 99.7+/-3.4 min, p=0.005)。 These differences were not due to the smoking status of the patient. Likewise, these values did not change significantly throughout the night yet, the lag phase value was significantly improved by treatment with CPAP (124.9+/-8.5 min; p<0.001). These results indicate that obstructive sleep apnoea syndrome is associated with abnormal lipid peroxidation and that this is improved by chronic use of Continuous positive airway pressure. These results can contribute towards explaining the high prevalence of cardiovascular diseases seen in Obstructive sleep apnoea syndrome.