TY - T1的异常睡眠呼吸暂停患者脂质过氧化JF -欧洲呼吸杂志》乔和J SP - 644 LP - 647欧元六世- 16 - 4盟Barcelo,非盟——产生、C AU - Barbe F AU -维拉,米非盟-脑桥,年代盟——Agusti AG Y1 - 2000/10/01 UR - //www.qdcxjkg.com/content/16/4/644.abstract N2患者心血管疾病的患病率增加的阻塞性睡眠呼吸暂停综合征(群)。动脉氧合的兴衰,每个呼吸暂停可能增加脂质过氧化作用,有助于解释这种关联。在目前的研究中,作者决定群患者的脂质过氧化反应和治疗的效果持续气道正压(CPAP)。十四岁男性患者严重的群(59 + / 5呼吸暂停x h(1))(+钙)和13健康不吸烟、年龄相仿的男性志愿者进行了研究。Patients were studied at diagnosis and after treatment with CPAP for more than 1 yr (>4 h x night(-1)). A venous blood sample was obtained early in the morning after fasting all night. In patients with OSAS, a sample before and during sleep was also obtained. Low density lipoprotein (LDL) particles were isolated by sequential ultracentrifugation. Their level of oxidation was determined by the thiobarbituric acid assay (TBARs), and their susceptibility to oxidation by the lag phase measurement. Patients with OSAS showed higher TBARs (28.1+/-2.8 versus 20.0+/-1.8 nmol x malondialdehyde x mgLDL protein(-1), p=0.02) and shorter lag phase values (83.8+/-3.4 versus 99.7+/-3.4 min, p=0.005) than controls. These differences were not due to the smoking status of the patient. Likewise, these values did not change significantly throughout the night yet, the lag phase value was significantly improved by treatment with CPAP (124.9+/-8.5 min; p<0.001). These results indicate that obstructive sleep apnoea syndrome is associated with abnormal lipid peroxidation and that this is improved by chronic use of Continuous positive airway pressure. These results can contribute towards explaining the high prevalence of cardiovascular diseases seen in Obstructive sleep apnoea syndrome. ER -