TY - JOUR T1 -慢性阻塞性肺疾病加重期诱导痰中鼻病毒检测JF -欧洲呼吸杂志JO - Eur Respir J SP - 677 LP - 683 DO - 10.1034/ J .1399-3003.2000.16d19。x VL - 16 IS - 4 AU - Seemungal, TA AU - Harper-Owen, R AU - Bhowmik, A AU - Jeffries, DJ AU - Wedzicha, JA Y1 - 2000/10/01 UR - //www.qdcxjkg.com/content/16/4/677.abstract N2 -普通感冒与慢性阻塞性肺疾病(COPD)加重有关。然而，普通感冒病毒(人鼻病毒)在COPD加重时产生症状和低气道炎症的作用尚不清楚。33例中度至重度COPD患者在基线时观察，当时记录了前一年胸部感染的数量，在COPD加重时观察到急性。在加重发作后48 h及基线时间内，取鼻吸液和诱导痰进行鼻病毒逆转录聚合酶链反应(RT-PCR)分析和测定细胞因子水平。将症状记录在日记卡上，并测量一秒钟用力呼气量(FEV1)和用力肺活量(FVC)。在加重时，平均FEV1和FVC较基线显著下降(p<0.001)。43例急性加重中有10例与诱导痰中发现的鼻病毒感染有关。其中四个国家的鼻咽样本未检测到鼻病毒。所有基线样本均为鼻病毒阴性。 The simultaneous presence of increased nasal discharge/nasal congestion (in 26 of the 43 exacerbations) and increased sputum (29 exacerbations) was strongly associated with the presence of rhinovirus (odds ratio 6.15; p=0.036). Total symptom scores were greater for rhinovirus as compared to nonrhinovirus exacerbations (p=0.039). Median baseline sputum interleukin-6 levels rose from 90.2 to 140.3 pg x mL(-1) at exacerbation (p=0.005); the change was greater in the presence of rhinovirus infection (p=0.008). Rhinovirus infection can be detected at chronic obstructive pulmonary disease exacerbation. This is associated with elevation of lower airway interleukin-6 levels, which may mediate lower airway symptom expression during chronic obstructive pulmonary disease exacerbations. ER -