TY -的T1 -表面活性剂蛋白基因,B和D标记等位基因在慢性阻塞性肺疾病的墨西哥人口JF -欧洲呼吸杂志》乔和J SP - 482 LP - 490欧元六世——18 - 3盟郭x盟——林、氯。AU -林,z . AU - Montano m . AU - Sansores r·王盟- g . AU - DiAngelo s . AU -帕尔多,a . AU -塞尔曼,m . AU - Floros j . Y1 - 2001/09/01 UR - //www.qdcxjkg.com/content/18/3/482.abstract N2 -慢性阻塞性肺疾病(COPD)的特点是慢性炎症。这很可能是环境和遗传因素复杂相互作用的结果。由于肺表面活性剂成分在正常肺功能、先天性宿主防御和肺部炎症中发挥重要作用，本研究调查了表面活性剂蛋白基因参与某些COPD病例的假设。在COPD患者(n=97)和吸烟者(n=82)或非吸烟者(n=99)中进行表面活性剂蛋白(SP)-A、SP- b、SP- b连锁微卫星和SP- d标记等位基因的基因型分析。进行单因素和多因素logistic回归分析。COPD与吸烟者之间的回归分析结果显示，基于比值比(OR >2.5)， COPD易感等位基因(AA62_A, B1580_C, D2S388_5)。该模型对COPD发展的预测能力较好(c=0.926)。检测等位基因-等位基因(B1580_C和D2S388_5)和等位基因-环境(即吸烟)相互作用。当吸烟者对照组与非吸烟者对照组比较时，标记基因D2S388_5似乎是吸烟独立的(p=0.874)，而标记等位基因AA62_A (p=0.045)和B1580_5 (p=0.007)是吸烟依赖的。 Males were at higher risk (OR=6.05, p=0.001), and smoking (>50 packs·yr−1) increased risk (OR=5.38, p=0.007). Males and alleles of loci flanking SP-B were associated with more severe cases (forced expiratory volume in one second/forced vital capacity ⪕40%). The present results indicate that the surfactant protein alleles may be useful in chronic obstructive pulmonary disease by either predicting the disease in a subgroup and/or by identifying disease subgroups that may be used for therapeutic intervention. These observations should now be confirmed in a larger study, designed according to strict epidemiological criteria. This work was supported by NIH R37 HL34788 and the General Clinical Research Center at the Pennsylvania State University College of Medicine. ER -