% 0期刊文章% m . Ledson % m . Gallagher % c.a哈特% m·沃尔什% T喷雾肝素伯克不过殖民成人囊性纤维化患者% D 2001% R 10.1183 / 09031936.01.17100360 % J欧洲呼吸杂志% P 36-38 % V 17% N 1% X粘性带负电荷的囊性纤维化(CF)痰允许病原体的入侵,引起慢性炎症反应。肝素钠稀释痰液通过减少粘蛋白分子氨基负电荷,改变其分子间氢键,具有离子屏蔽其polyionic根。肺内也有抗炎作用。因此,它可能是有用的在CF患者的治疗。为了测试这个,六个充分了解洋葱不过殖民稳定成人CF患者,收到7天每天25000 IU喷雾硫酸肝素。主观的痰液参数,肺量测定法,血小板、凝血参数和血清和唾液白介素(IL) 6和8应承担的测量之前和之后的治疗。所有病人容忍没有证据的肝素出血,血小板减少或改变凝固参数。在肺量测定法没有变化,但减少白细胞介素(痰地理IL 6, p = 0.01;痰地理IL 8, p = 0.002;地理血清IL 6, p = 0.02;血清IL 8,应承担p = 0.02)。 Sputum was easier to expectorate (p<0.04), with a trend towards thinner sputum (p=0.07) but no change in sputum volume.Heparin therapy was well tolerated and had an anti-inflammatory effect, with subjective sputum mucolysis. Further studies are necessary to define the role of heparin in the treatment of cystic fibrosis patients. %U //www.qdcxjkg.com/content/erj/17/1/36.full.pdf