ty -jour t1-童年哮喘的增加即将结束？来自意大利罗马的三个学童调查的调查结果 - 欧洲呼吸杂志JO -EUR RESSIR J SP -881 LP -886 VL -17 IS -5 AU -RONCHETTI -RONCHETTI，R.AU -VILLA，M.P.Au -Barreto，M.Au -au -Rota，R.Au -Pagani，J.Au -Martella，S.Au -Falasca，C.Au -Paggi -Paggi，B.Au -Guglielmi，F.Au -Ciofetta，G。Y1-2001/05/01 UR -http：//www.qdcxjkg.com/content/17/5/881.abstract N2-评估了哮喘患病率的时间趋势，罗马学童的哮喘和特温家族的家族史。该研究人群由所有儿童（6-14岁）组成，在罗马的两所小学就读，该小学位于城市地区，在社会经济条件和环境污染上明显不同。1974年，1992年和1998年在2,259、1229和1,139名儿童中进行了三项基于问卷调查的调查。在1974 - 1992年期间，男性和女性哮喘的患病率显着增加，并在1992 - 1998年间保持稳定。在随后出生的4年期间出生的年龄组中，它几乎是线性增加的，对于1962 - 1965年至1982 - 1985年出生的孩子（4.4％–12.5％），在1985年以后出生的儿童中保持非常稳定。男性的趋势比女性（约0.55％·yr -1对0.25％·yr -1），男性：女性哮喘比率增加（1974年1:38; 1994年； 1992年1:84，在1992年和1:621998）。 No single environmental factor, including area of residence, seemed to influence the prevalence of asthma. Family history of asthma and atopy also increased steadily (0.72%·yr−1 and 0.30%·yr−1 respectively) more than doubling during the 24-yr study period. The strong relationship between asthma and a family history of atopy not only persisted but also strengthened over time (23.3% of asthmatic children belonged to families with atopic illnesses in 1974 but 44.2% in 1998). The environmental factors that might explain the almost three-fold rise in childhood asthma between 1974 and 1992 remain unknown but the genetic background of the disease has presumably remained unchanged since the early 1970s. The fact that the prevalence of asthma increased no further during the past 6 yrs suggests that the progressive induction of asthma symptoms in genetically predisposed subjects is a self-limiting process that has probably come to an end in the authors' study area. ER -