％0期刊文章％a o'hickey，sp％a rees，pj％lee，th％t气道对腺苷5'单磷酸的响应能力在吸入高渗盐水％D 1989％j欧洲呼吸期j欧洲呼吸杂志％p 923-928％v 1989％J2％N 10％X我们希望确定高渗盐水（HS）挑战后的耐火期是否是由于肥大细胞介质耗竭引起的。因此，在HS气溶胶吸入后确定了通过肥大细胞组胺释放诱导支气管收缩的腺苷5'单磷酸（AMP）的气道反应性。九名哮喘受试者三次参加了实验室。一小时后，在第一天进行HS挑战之后，第二次HS挑战。在第2天，进行了AMP挑战。在第3天，一小时后进行了HS挑战，并进行了AMP挑战。气道响应能力（PD35 SGAW）对最初的HS挑战范围为12至315升气溶胶（平均47 L）。气道对第二次HS挑战的反应范围为8至800 L（平均102 L P = 0.035，n = 9）。在HS挑战之后，对AMP的气道响应从基线时从0.44增加到14.0 mumol（平均2.37 mumol）到0.3至15.5（平均1.3 mumol）（p = 0.05）。 There was a linear correlation between baseline AMP responsiveness and baseline HS responsiveness (r = 0.911, p = 0.001). There was no correlation between the degree of refractoriness and the change in AMP responsiveness (r = 0.1, p = 0.9). Thus airway responsiveness to AMP increased significantly after inhalation of HS aerosol and this increase was independent of refractory behaviour. Our results suggest that the refractory period to HS is not due to mediator depletion. %U //www.qdcxjkg.com/content/erj/2/10/923.full.pdf