@article {Choi786，作者= {Choi，G。和Schultz，M.J。和Van Till，J.W.O。和Bresser，P。和Van der Zee，J.S。和Boermeester，M.A。和Levi，M。和Van der Poll，T。}，title = {肺炎期间受干扰的肺泡纤维蛋白周转率仅限于感染部位}，音量= {24}，数字= {5}，页面= {5}，页面= {5}{786---789}，年= {2004}，doi = {10.1183/09031936.04.0044.00140703}，Publisher = {欧188bet官网地址洲呼吸社会}，摘要= {严重感染与全身性止血平衡的深刻变化有关凝血和抑制纤维蛋白溶解。在肺泡室内，在肺部炎症期间已经描述了类似的障碍。目前的作者研究了在呼吸机相关肺炎（VAP）期间是否受到局部止血的影响。在五名单侧VAP的患者中，从感染部位（如胸部X光片上确定）和对侧未感染的肺（没有临床或X射线照相异常），从受感染部位（如胸部X光片上确定）获得支气管肺泡灌洗液（BALF）。比较感染和未感染的肺之间的凝血和纤维蛋白溶解标记。共有10名健康志愿者和10名没有肺炎的机械通风患者用作对照。 Strong activation of coagulation (high levels of thrombin-antithrombin complexes, soluble tissue factor and factor VIIa) was detected in BALF from infected lungs, compared with that from noninfected lungs and controls. Furthermore, in infected lungs, fibrinolysis was depressed, with high levels of plasminogen activator inhibitor type 1. In conclusion, ventilator-associated pneumonia is characterised by a hypercoagulant state at the site of infection.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/24/5/786}, eprint = {//www.qdcxjkg.com/content/24/5/786.full.pdf}, journal = {European Respiratory Journal} }