RT期刊文章SR电子T1嗜酸性气道炎症和COPD的加剧：一项随机对照试验JF欧洲呼吸杂志JO EUR RESSIR J FD欧洲呼吸协会SP 906 OP 913 DO 10.1183/09031936.009031936.00146306 VO 29 IS 5 a1 siva，R.A11 Green188bet官网地址R. H. A1 Brightling，C。E. A1 Shelley，M.A1 Hargadon，B.A1 McKenna，S.A1 Monteiro，W.A1 Berry，M.A1 Parker，D.A1 Wardlaw，A.J.A1 Pavord，I。D。YR 2007 UL HTTP：//www.qdcxjkg.com/content/29/5/906.ABSTRACTAB证据表明，嗜酸性气道炎症在严重的慢性阻塞性肺疾病（COPD）加剧的发病机理中很重要。目前的作者检验了以下假设：旨在减少嗜酸性粒细胞计数的管理策略与COPD加剧的减少有关。共有82例COPD患者被随机分为两组。根据传统准则（英国胸腔协会（BTS）组）对一组进行治疗，另一组（痰液组）接受了使用诱导的痰嗜酸性粒细胞计数评估的其他目的，以最大程度地减少嗜酸性气道炎症。主要结果是加重，被归类为轻度，中度或重度。在BTS和痰中，每位患者每年严重加重的频率分别为0.5和0.2（平均还原62％）。大多数这种益处仅限于嗜酸性气道炎症患者。轻度和中度加重的频率没有差异。 The average daily dose of inhaled or oral corticosteroids during the trial did not differ between the groups. Out of 42 patients in the sputum group, 17 required regular oral corticosteroids to minimise eosinophilic airway inflammation. A management strategy that aims to minimise eosinophilic airway inflammation, as well as symptoms, is associated with a reduction in severe exacerbations of chronic obstructive pulmonary disease.