Ty -jour t1-在严重的COPD JF中，小气道中的Galectin -3表达和上皮中性粒细胞增加 - 欧洲呼吸杂志JO -EUR RESSIR J SP -914 LP -914 LP -922 DO -10.1183/09031936.000736.00073005Pilette，C.Au -Colinet，B.Au -au -aus，R.Au -André，S。Au -Kaltner，H。Au -Gabius，H -J。Au -Delos，M.Au -Vaerman，J -P。Au -Declamer，M.Au -au -y. Y. Y. Y. Y1-2007/05/01 UR -http：//www.qdcxjkg.com/content/content/29/5/914.4.abstract n2 -Galectins -1和-3调节上皮增殖/凋亡和中性粒细胞活化，并与肺癌和哮喘有关。甘肠蛋白在慢性阻塞性肺疾病（COPD）中的作用，其特征是上皮变化和中性粒细胞浸润，仍然未知。在本研究中，通过免疫组织学评估了Galectin -1和-3的表达，在来自八名严重COPD患者的肺样本的支气管上皮中，并与9名非吸烟者和6名没有COPD的吸烟者相比。发现与上皮增殖（KI-67），组织炎症和肺功能有关。与非吸烟者和吸烟者相比，COPD患者的小型气道仅在COPD患者的小气道中增加上皮乳糖素3免疫染色。相比之下，在吸烟者组的小气道中，lectectin-1仅显着增加。 Ki-67+ epithelial cells and neutrophils were increased in the small airways of COPD patients when compared with smokers. Furthermore, intra-epithelial neutrophils correlated in the small airways with Ki-67+ epithelial cells and with the forced expiratory volume in one second/forced vital capacity ratio. However, no correlation was observed with galectin expression. The present study supports the hypothesis that distal airways represent an important site for detecting changes in chronic obstructive pulmonary disease. In patients with severe disease, an increased galectin-3 expression and neutrophil accumulation in the small airway epithelium was demonstrated, correlating with epithelial proliferation and airway obstruction. ER -