Ty -jour t1-阻塞性睡眠呼吸暂停综合症患者的时钟基因功能障碍JF-欧洲呼吸杂志Koyanagi，S。au -Endo，M。au -au -au -au -au -fukuoka，Y。au -Miyata，M.Au -au -au -au -au -au -au -chikumi -chikumi，h. au -ohdo -ohdo，S.Au -au -au -au -au -shimizu，Shimizu，Shimizu，E. Y1-2008/07/01 UR -http：//www.qdcxjkg.com/content/32/1/105.abstract N2-时钟基因调节哺乳动物昼夜节律，而时钟基因的功能障碍可以对各种弊端产生贡献。为了研究阻塞性睡眠呼吸暂停综合征（OSA）是否影响时钟基因的功能，目前的作者在体外和体内检查了周期1（PER1）mRNA表达。在八名健康受试者和八名OSAS患者中，测量了外周全血中血浆去甲肾上腺素，血清白介素（IL）-6，高敏C反应蛋白（HSCRP）和PER1 mRNA表达。在体外IL-6或去甲肾上腺素刺激下检查了培养细胞中PER1 mRNA的表达。在体内给予去甲肾上腺素后，检查了大脑中的PER1 mRNA表达。OSAS患者的血清IL-6，HSCRP和血浆去甲肾上腺素的浓度升高，但通过持续阳性气道压力（CPAP）治疗提高。OSAS患者的CPAP在02:00 h时，外周血中的PER1 mRNA表达显着降低。用IL-6刺激不会直接在体外诱导PER1 mRNA。 Administration of noradrenaline induced Per1 mRNA in the cerebral cortex of mice in vivo. The current study revealed that obstructive sleep apnoea syndrome caused clock gene dysfunction, and continuous positive airway pressure helped to improve it. Sympathetic activation and elevation of the plasma noradrenaline concentration in obstructive sleep apnoea syndrome may be one of the factors involved in disorders of Period1 mRNA expression. ER -