AU - Bartalesi, F. AU - Vicidomini, S. AU - Goletti, D. AU - Fiorelli, C. AU - Fiori, G. AU - Melchiorre, D. AU - Tortoli, E. AU - Mantella, A. AU - Benucci, M. AU - Girardi, E. AU - Cerinic, M. M. AU - Bartoloni，A. TI - QuantiFERON-TB Gold和TST均可用于自身免疫性疾病的潜伏性结核感染筛查AID - 10.1183/09031936.00107608 DP - 2009年3月01日TA -欧洲呼吸杂志PG - 586—593 VI - 33 IP - 3 4099 - //www.qdcxjkg.com/content/33/3/586.short 4100 - //www.qdcxjkg.com/content/33/3/586.full SO - Eur Respir J2009年3月01日;33ab -在开始肿瘤坏死因子-α抑制剂治疗之前，必须筛查活动性结核病(TB)和潜伏性结核病感染(LTBI)。然而，对于在这一人群中检测LTBI的最佳策略尚未达成一致。本研究的目的是分析结核菌素皮肤试验(TST)和QuantiFERON®-TB Gold in-tube (QFT-GIT)在免疫介导炎症性疾病(IMID)患者LTBI检测中的表现。TST和QFT-GIT前瞻性地在398名连续的IMID受试者中进行，310人(78%)接受免疫抑制治疗，只有16人(4%)接种了Calmette-Guérin(卡介苗)疫苗。5名受试者(1.2%)发现QFT-GIT结果不确定。总的来说，393名受试者中有74名(19%)tst阳性，52名(13%)qft - git阳性。TST和QFT-GIT结果一致性良好(87.7%):13例QFT-GIT阳性/TST阴性，35例QFT-GIT阴性/TST阳性。通过多变量分析，两项试验均与年龄显著相关。 Only the TST was associated with BCG vaccination and radiological lesions of past TB. Use of immunosuppressive drugs differently modulated QFT-GIT or TST scoring. Use of the QuantiFERON®-TB Gold in-tube, as a screening tool for latent tuberculosis among immunomediated inflammatory disease subjects, is feasible. Until further data will elucidate discordant tuberculin skin test/QuantiFERON®-TB Gold in-tube results, a strategy of simultaneous tuberculin skin and QuantiFERON®-TB Gold in-tube testing in a low prevalence bacillus Calmette–Guérin vaccinated population, should maximise potentials of latent tuberculosis diagnosis.