RT SR电子T1条cyclooxyge》杂志上nase theory of aspirin-induced asthma JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 588 OP 593 VO 3 IS 5 A1 Szczeklik, A YR 1990 UL //www.qdcxjkg.com/content/3/5/588.abstract AB Aspirin-induced asthma is a distinct clinical syndrome which affects about 10% of adult asthmatics. In these patients aspirin and several other analgesics precipitate asthmatic attacks. The idea that the attacks might result from the specific inhibition of a single enzyme, namely cyclooxygenase, has gained both experimental and clinical support. It stimulated a number of hypotheses on the mechanism of bronchoconstriction. All these hypotheses, here discussed, operate within the framework of the cyclooxygenase theory. Their major assumption is that inhibition of cyclooxygenase triggers specific biochemical reactions which lead to open asthma attacks.