%0期刊文章%A Derom, E. %A Louis, R. %A Tiesler, C. %A Engelstätter, R. %A Kaufman, j . m。A Joos, g . F. T环索尼德和氟替卡松对持续性哮喘患者皮质醇分泌的影响J欧洲呼吸杂志除了CIC 160µg·天−1和沙美特罗50µg·日2次外，我们比较了32例持续性哮喘患者使用环索尼德(CIC)和丙酸氟替卡松(FP)的系统和临床效果，采用随机双盲、安慰剂对照、双假人，五期跨界设计。所有患者均表现出刺激性浓度，导致用力呼气量在1秒内下降20% (PC20)甲基胆碱<8 mg·mL−1和PC20腺苷<60 mg·mL−1。主要结果为7天后24小时血清皮质醇抑制。次要结局是9天后PC20甲基胆碱和腺苷的变化。与安慰剂相比，FP 500µg·day−1和1000µg·day−1分别显著抑制皮质醇分泌-46.2(95%可信区间(CI) -83.8 - -8.5) nmol·L−1和-76.1 (95% CI -112.9 - -39.3) nmol·L−1。CIC剂量(320或640µg·day−1)均无显著抑制作用(分别为-28.2 (95% CI -65.5-9.2) nmol·L−1和-37.3 (95% CI -74.7-0.0) nmol·L−1)。FP 1000µg·天−1与两种CIC处理之间的差异具有统计学意义(CIC 320µg·天−1:-48.0 (95% CI -84.8 - -11.1) nmol·L−1;中投640µg·−1天:-38.8 (95% CI -75.7 - -1.9) nmol·L−1)。 Compared with placebo, the increase in PC20 adenosine after the four treatments was small, but significant. Greater improvements in PC20 adenosine were seen with FP 500 µg·day−1 (1.8 (95% CI 1.0–2.6) doubling concentrations) compared with CIC 320 μg·day−1 (0.9 (95% CI 0.1–1.7) doubling concentrations). No significant difference was seen between CIC 640 μg·day−1 and FP 1,000 μg·day−1. For a similar decrease in hyperresponsiveness, cortisol secretion was suppressed significantly with moderate-to-high doses of fluticasone propionate, but not with ciclesonide. %U //www.qdcxjkg.com/content/erj/33/6/1277.full.pdf