作者:M. C. %A van Gent, M. W. F. A Plokker, H. W. M. A Westermann, C. J. J. A Kelder, J. C. %A Mager, J. J. A Overtoom, T. T. %A Schonewille, W. J. %A Thijs, V. A Snijder先兆偏头痛(MA)与心脏右至左分流相关。我们前瞻性地研究了遗传性出血性毛细血管扩张症(HHT)中肺动静脉畸形(PAVMs)和MA之间的关系。所有220例接受高分辨率胸部计算机断层扫描进行PAVM筛查的HHT患者被纳入前瞻性研究。筛查前，196名患者(57%为女性;平均±sd年龄44.6±15.2岁)。两位神经科医生根据国际头痛学会标准诊断为偏头痛。70例(36%)患者出现PAVM。PAVM存在时MA患病率为24%，无PAVM时为6% (OR 4.6, 95% CI 1.84-11.2;p = 0.001)，通过多因素分析，MA是PAVM存在的独立预测因子(OR 3.6, 95% CI 1.21-10.5; p = 0.02). A PAVM was present in 68% of the patients with MA compared with 32% in the non-migraine controls (OR 4.6, 95% CI 1.84–11.2; p = 0.001), and a PAVM was an independent predictor for MA using multivariate analysis (OR 3.0, 95% CI 1.00–9.20; p = 0.05). In conclusion, PAVMs are associated with MA in HHT patients. %U //www.qdcxjkg.com/content/erj/34/4/882.full.pdf