TY -的T1 -自主尼珥的临床意义vous system disturbances in pulmonary arterial hypertension JF - European Respiratory Journal JO - Eur Respir J SP - 704 LP - 705 DO - 10.1183/09031936.00165509 VL - 35 IS - 3 AU - Raffestin, B. AU - Leroy, M. Y1 - 2010/03/01 UR - //www.qdcxjkg.com/content/35/3/704.abstract N2 - To the Editors: We read with great interest the editorial by Naeije and van de Borne 1 on clinical relevance of autonomic nervous system disturbances in pulmonary arterial hypertension. This editorial applies to the study of Wensel et al. 2 investigating heart rate variability and baroreflex sensitivity in patients with severe pulmonary arterial hypertension (PAH). In their editorial, R. Naeije and P. van de Borne discuss the cause of exercise hyperventilation in PAH, as well as in patients with congestive heart failure, and attribute it mainly to an increased chemosensitivity on the basis of some previous inert gases studies. In fact, three factors determine the ventilatory response to exercise, 1) the CO2 production, 2) the ratio of physiological dead space (VD) to tidal volume (VT), VD/VT, 3) the arterial CO2 tension or set point. By analysing each factor in quantitative terms, it is possible to determine the role of each in the high ventilatory response observed in patients … ER -