Ty -jour t1-粘膜炎症和重塑中监测痰嗜酸性粒细胞：试点研究JF-欧洲呼吸杂志JO -EUR RESSIR J SP -48 LP -48 LP -53 DO -10.1183/09031936.001936.00130008 VL -35 IS -1 AU -CHAKIR，J。Au -Loubaki，L。Au -Laviolette，M.Au -Milot，J.Au -Biardel，S.Au -Jayaram，L.Au -Pizzichini，M.Au -Pizzichini -pizzichini，E.Au -Au -Hargreave- Hargreave，F.E.Au -Nair -Nair -Nair -Nair，P。au -boulet，l -p。Y1- 2010/01/01 UR -http：//www.qdcxjkg.com/content/35/1/48.abstract N2-哮喘患者痰中嗜酸性粒细胞计数的归一化，减少了嗜酸性粒细胞增生。但是，该策略对气道重塑的影响尚待确定。我们比较了由痰嗜酸性粒细胞（痰液策略，SS）或临床标准（临床策略，CS）引导2年治疗后的支气管炎症和胶原沉积。作为一项试点研究，将20名轻度哮喘患者随机分配到CS或SS策略。当确定维持控制所需的最低治疗时，获得了支气管活检，并继续进行2年。活检对炎性细胞，粘蛋白5A（MUC5A）和胶原蛋白进行免疫染色。在研究开始和结尾，在SS和CS组中，吸入的皮质类固醇的平均剂量相似。在研究结束时，两组的强迫呼气量增加了1 s。 In SS, mucosal lymphocyte and eosinophil counts, but not neutrophils, were reduced at the end of the study. In CS, only activated eosinophil and neutrophil counts decreased. MUC5A staining decreased in SS but not CS. No change in collagen deposition underneath the basement membrane was observed in either strategy. Treatment strategies that normalise sputum eosinophils also reduce mucosal inflammatory cells and MUC5A expression, but do not change subepithelial collagen deposition in mild to moderate asthma. ER -